Cushing's syndrome is a syndrome named after Boston surgeon Harvey Cushing (1869–1939) that refers to a severe systemic illness most usually seen in female individuals, which includes neurologic symptoms and changes in bone structure, hypertension, and diabetes. The adrenocorticotropic hormone-secreting tumor is the most serious condition encountered by any of the pituitary tumors and can result in a necessary complete removal of the tumor, including the pituitary gland.