Substance abuse refers to the use of a mood -altering substance in such a way that it is either socially unacceptable or impairs social, medical and/or occupational functioning.
See also:
"Substance abuse" is in the UNSPSC Code "85101506"
  Substance abuse hospital services
Other /More definition:
Substance abuse refers to the use of a mood-altering substance in such a way that it is either socially unacceptable or impairs social, medical and/or occupational functioning.
Other /More definition:
Substance abuse The pattern of maladaptive and psychoactive substance use that leads to significant impairment in social and occupational roles and in hazardous situations or distress.
Moreover, Substance abuse is a diagnosis that involves one or more harmful and repeated negative consequences of substance use over the last 12 months.